surmount-1 tirzepatide obesity nejm 2022 weight loss percent vs Semaglutide: Winner? ๐ ๐ 72-Week Data: Tirzepatide: ~20% body weight loss Semaglutide: ~14% body weight loss ๐ก Tirzepatide shows greater weight & HbA1c reduction, but cost, side Retatrutide Phase 2 NEJM Trial:
Description
Metabolism Tirzepatide is metabolized by proteolytic cleavage of the peptide backbone, beta-oxidation of the C20 fatty diacid moiety and amide hydrolysis
Both medicines are given as shots under the skin once weekly using a pen-like device
Overusing preserved sterile water beyond recommended days risks bacterial contamination
Dose adjustments to those drugs are usually needed
Individual results vary significantly, and some patients respond better to one medication than the other
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