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DPP-4 inhibition is an interesting line of therapy for treating Type 2 Diabetes Mellitus (T2DM) and is based on promoting the incretin effect

These findings align with results from the SURMOUNT-5 trial and an earlier real-world study from Truveta Research, with similar patterns observed across different study designs and patient populations

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When linagliptin was co-administered with a GIP-antagonising antibody, the impact of linagliptin was partially blunted in wild-type mice and was fully blocked in GcgRANull mice