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It should not be used by people with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2), and Wegovy and levothyroxine treatment should always be managed under appropriate medical supervision

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Other groups requiring careful evaluation include: Patients with a history of pancreatitis a causal relationship between incretin-based therapies and pancreatitis has not been definitively established, but UK SmPCs advise caution in those with a prior history

Two large cohort studies found no increased risk of HZ associated with SGLT-2i use, and these agents served as negative control outcomes in sensitivity analyses [20, 21]