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Document whether appetite suppression diminished, whether the same dose produces fewer gastrointestinal effects than previously, and whether metabolic parameters began deteriorating
Whilst attractive as a theory, it should, nevertheless, be borne in mind that the majority of the studies cited above have been carried out in rodents or have examined isolated islets/-cells under in vitro or ex vivo conditions, and whether a local pancreatic DPP-4/GLP-1 system plays an important role in normal human physiology or in the pharmacological effect of DPP-4 inhibitors is not clear
Sublingual liquid formulations represent an alternative delivery method

Many patients report subjective improvements in energy levels after initiating GLP-1 therapy, though this effect is not universal and reflects multiple contributing factors rather than direct pharmacological stimulation
CAN GLP-1 BE COMBINED WITH OTHER WEIGHT LOSS TREATMENTS