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27, Supplementary Tables 2, 3)
Metformin: Mechanisms in Human Obesity and Weight Loss
With a foreword by Dr Ellie Cannon
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It binds directly to fat cells and stimulates lipolysis, the process by which stored triglycerides are broken down into free fatty acids the body can burn
The FDA also recommends examining hard clinical endpoints such hepatic decompensations, transplant free survival, and all-cause mortality, although these results are not necessarily needed prior to drug approval given the long length of follow up potentially required
