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For studies with zero events in both arms, continuity correction was performed, and their data were included in TSA analyses

Jejunal tissue was isolated, first cleaned with PBS, then immediately flushed and stored in cold biopsy preservation buffer (BIOPS) (pH 7.1 (5.77 mM Na 2+ ATP, 10 mM Ca-EGTA buffer, 0.1 M free calcium, 6.56 mM MgCl 2 6H 2 O, 20 mM taurine, 20 mM imidazole, 60 mM K-lactobionate, 15 mM phosphocreatine, 0.5 mM DTT, 50 mM MES)

Clinical Evidence on GLP-1 Therapy and Diabetic Neuropathy Large cardiovascular outcome trials such as LEADER, SUSTAIN-6, and REWIND were not designed specifically to measure neuropathy progression

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Side effects and risks : Though GLP-1 agents are generally well tolerated, they carry risk of gastrointestinal effects, possible rare pancreatitis, effects on gallbladder, etc

11.5.2 Monitors and communicates factors and barriers affecting client/patient progress in meeting goals