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Inflammatory proteins associated with Alzheimers disease reduced by a GLP1 receptor agonist: A post hoc analysis of the EXSCEL randomized placebo controlled trial

81 In addition to its hypoglycemic effect, the neuroprotective effect of SGLT-2is may be another evidence that it can cross the BBB

However, the incidence of clinically meaningful muscle wasting under GLP-1RA therapy remains to be determined through prospective studies with standardized assessment methods

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However, the relevance of these findings to humans remains uncertain because human thyroid C-cells express GLP-1 receptors at much lower levels than rodent C-cells, suggesting potentially different susceptibility to GLP-1-mediated effects