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Setting Claims data from Medicare and two large commercial insurance databases in the United States from April 2013 to April 2022

7.2 Relaxin-3 and the behavioral dimension of metabolic disease Relaxin-3, a member of the relaxin peptide family predominantly expressed in the nucleus incertus, signals through the RXFP3 receptor and exerts pronounced effects on feeding behavior, arousal, stress responsiveness, and cognitive processing in animal models (Smith et al., 2014)

Nevertheless, collectively these findings provide further support for a pleiotropic impact of GLP-1 on the mesolimbic circuitry and reward behavior

"It's a worthwhile discussion for the patient and provider to really think about what is going to help them stay on the medication longer," says Watanabe