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There are significant demographic differences in adverse reactions: 57.5% of adverse events (AEs) in females occur after one year of treatment, whereas 40.5% in males are concentrated within 30 days
Commonly reported symptoms of menopause include hot flashes, night sweats, vaginal dryness, sleep disturbances, mood swings and weight gain, 1 with an estimated 70% of menopausal women experiencing weight gain

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The acute effects of exendin-4 to reduce food intake and to improve glucose handling are preserved upon knockdown of GLP-1R in the VMH [715], indicating that the effects of central GLP-1R activation on eating and BAT thermogenesis are mediated by at least partially separate brain areas and circuitries

"Lowering the dose may become a viable maintenance strategy once a healthy weight is reached, though this approach is still under study," she said

The methods vary
