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Pharmacokinetics: Bioavailability: ~90% Half-life: ~2430 hours Metabolism: Minimal hepatic metabolism Excretion: Mainly renal Adverse Effects: Headache Nausea Abdominal pain Diarrhea Interesting Fact: Unlike older prokinetic agents (like cisapride), prucalopride has high receptor selectivity, reducing the risk of cardiac arrhythmias a major safety improvement

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GIP receptors exist in fat tissue, bone, and the brain

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For now, oral Wegovy is the only oral GLP-1 you can actually start in the UK

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S., Lefkowitz, R

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Its safety profile has also been well-established, with minimal side effects reported

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PARP1 may regulate the E2F1 transcription factor by poly-ADP-ribosylation, reducing the apoptosis rate of cancer cells that had been induced by E2F1 activation

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