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de la Monte SM, Wands JR

The GLP1R agonist liraglutide reverses mania-like alterations and memory deficits induced by D-amphetamine and augments lithium effects in mice: Relevance for bipolar disorder

They enhance glucose-dependent insulin secretion, suppress glucagon release, slow gastric emptying, and reduce appetite via central hypothalamic pathways, leading to lower energy intake and improved glycemic control

Chronic delivery of Ex-9 to the lateral ventricle in rats increased bodyweight in chow- and high-fat dietfed animals (97)

The honest summary: Retatrutide probably does produce modestly greater weight loss than tirzepatide at maximum doses, potentially in the range of 36 percentage points of body weight

doi: 10.1016/j.immuni.2023.06.021