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Consistent dosing

An increase in GLP-1 levels as well as a reduction in IBS-SSS was found following LFD

Similarly, the sample size in the TRIUMPH1 knee OA basket is designed to provide at least 90% power to detect a clinically meaningful benefit of retatrutide 9 and 12 mg versus placebo in the change in WOMAC pain subscale score, assuming each dose is analysed separately in parallel using a Satterthwaite t test at a 2sided significance level of 0.0125, accounting for differences that have been observed historically in variability between placebo and active arms

Hypoglycaemia management follows standard protocols, with review of concomitant glucose-lowering medications and potential dose reduction of insulin or sulphonylureas

We also performed similar MAPS experiments testing the response of the chimeric FSHR-GLP-1 NRR -Notch receptor

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