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A four-minute drive north of the Illinois-Wisconsin border in 'America's Dairyland,' Eli Lilly is staking one of its largest-ever manufacturing bets to continue its dominance in obesity drugs and support a deep pipeline of next-generation medicines for the most lucrative pharmaceutical market.

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The impact of antidiabetic drugs on bone metabolism is drawing increasing attention due to the discovery of a correlation between type 2 diabetes mellitus an...