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Topiramate is one of many prescription drugs currently being used for weight management
The concept of interoception has been discussed academically for over a century, notably championed by physiologist Carl Lange and psychologist William James, who wrote in Principles of Psychology (James, 1918): If our hypothesis is true, it makes us realize more deeply than ever how much our mental life is knit up with our corporeal frame, in the strictest sense of the term
It induces metabolic reprogramming in response to hypoxia and growth factor signalling 18, 19 , partly by promoting transcriptional activation of glycolytic genes 20
PMID: 21562063
& Perry, R
doi:10.1097/txd.0000000000001558 11
