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Importantly, histone methylation/acetylation and DNA methylation play a central role in controlling gene expression, thus promoting the progression and metastasis of PCa

Coherus said the observationcommunicated in an FDA Form 483is readily addressable and the company continues to anticipate potential approval for toripalimab by year end 2023. Coherus and its partner Junshi Biosciences received a CRL for toripalimab in this indication requesting a quality process change in May 2022

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[DOI] [PMC free article] [PubMed] [Google Scholar] 145.Jais A, Bruning JC
