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The increased use of GLP-1 receptor agonists, particularly for the treatment of obesity, has been well documented

Intuitively, it would seem that GLP-1 use for obesity would reduce overall medical costs despite the increase in drug spending

GLP-1RAs reduce events linked to atherogenic cardiovascular disease (especially ischemic stroke) and also renal outcomes (FLOW trial with semaglutide), with a limited effect on heart failure

Because the cost of care rises as patient comorbidities increase, the value of treatment also increases

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Regarding renal effects, the evidence of SGLT2is in preventing kidney failure is more abundant than for GLP-1RAs, which showed a beneficial effect on albuminuria but not on hard kidney endpoints