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Pharmacologically mediated marked initial maternal body weight loss and reductions in body weight gain and food consumption coincided with an increase in early pregnancy losses and led to delivery of slightly smaller offspring at 0.075 mg/kg twice weekly (2X human exposure)

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Niazi, Emerging Frontiers in GLP-1 Therapeutics: A Comprehensive Evidence Base (2025)

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Sixth, patients with a history of pancreatitis or risk factors for pancreatitis are usually excluded during the screening phase