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Relevant for clinical practice, our findings show that treatment with semaglutide lowered the risk of MACE compared to sitagliptin, while tirzepatide showed at least comparable benefit to dulaglutide, an older GLP-1 receptor agonist with established cardiovascular efficacy

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2427 However, there are limitations to considering protein intakes relative to BM in the context of obesity and substantial weight loss, and expressing intakes relative to FFM may be preferable in this context

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doi: 10.1126/science.abd2985 75 MayiBSLeibowitzJAWoodsATAmmonKALiuAERajaA