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Patients with severe gastrointestinal motility disorders (such as gastroparesis), history of bowel obstruction, or significant abdominal surgical history should discuss their potential increased risk with their provider before starting weight loss injections

Incretin-based drug development As mentioned above, endogenous GLP-1 has a very short half-life (1-2 minutes) due to its rapid degradation by DPP4, limiting its utility for treatment as a therapeutic

Women may experience more variable results month to month due to hormonal fluctuations across the menstrual cycle

People who have tried the trend -- which involves mixing a spoonful of gelatin into warm water and drinking it 15 to 30 minutes before a meal -- have claimed in social media videos that the beverage helps people lose weight by forming a gel in the stomach and supposedly taking up space, signaling to the brain that they're getting full

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