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13 Classification of the drugs is based on the benefits of clinical studies (Table 2)

Particularly when you compare it to the risk of eye disease in the setting of diabetes, which is where most of this question has been studied

In rat, mouse and rabbit models without systemic inflammation, the other GLP1-receptor agonists (except exendin-4), dose dependently caused reduced fetal weight and/or growth, retardation of ossification, irregular ossification, and/or skeletal variants such as wavy ribs ( Table 1 )

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However, this concept should be taken cautiously, since many residues in the N-terminal region are still found to be essential for maximal receptor interaction