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Aspirin (Acetylsalicylic Acid) Mechanism: Irreversibly inhibits COX-1 enzyme thromboxane A inhibits platelet aggregation Indications: Acute coronary syndrome (ACS) Myocardial infarction (primary & secondary prevention) Stroke/TIA prevention Peripheral arterial disease Dose: Low-dose: 75100 mg/day for antiplatelet effect Higher doses: anti-inflammatory (not usually for antiplatelet) Side Effects: Gastrointestinal irritation / bleeding Allergic reactions Rare: Reyes syndrome (in children) Clopidogrel Mechanism: Irreversibly inhibits ADP (P2Y12) receptor on platelets prevents platelet activation and aggregation Indications: ACS (with or without stenting) Post-percutaneous coronary intervention (PCI) with stent Stroke/TIA prevention Peripheral arterial disease Dose: 75 mg orally once daily (after a loading dose in ACS: 300600 mg) Side Effects: Bleeding (less GI irritation than aspirin) Rare: thrombotic thrombocytopenic purpura (TTP)

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Understanding this interaction helps you make informed dietary choices while on treatment