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This approach was applied previously in drugs like semaglutide and tirzepatide

In addition, the choroid plexus and adipose tissue both produce tryptase, which can induce mast cell activation, ultimately leading to increased intracranial pressure

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It could be passive diffusion, active transport, cellular delivery and so on

Proton magnetic resonance spectroscopy ( 1 H MRS), with its extremely high sensitivity, is used for detecting and quantifying several endogenous tissue metabolites in a single acquisition, but it is not capable of tracking the activity of a metabolic pathway due to limitations related to water, lipid suppression, and magnetic field homogeneity [22]
