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Our study demonstrated that the statin-induced hyperglycemic effect was attributed to the Clostridium sp.-bile acids axis and provided important insights into adjuvant therapy of UDCA to lower the adverse risk of statin therapy

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Published in the New England Journal of Medicine in 2015 by Pi-Sunyer et al., it randomized participants 2:1 to liraglutide 3.0 mg or placebo, both with lifestyle counseling

For the efficacy estimand, the LSM change in HbA1c from baseline at week 52 as the primary endpoint was 2.24%, 2.43%, and 2.58% with tirzepatide 5, 10, and 15 mg, respectively, versus 1.44% with insulin glargine

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