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Discussion In this database study, treatment with semaglutide (against sitagliptin, a placebo proxy) led to a reduced risk of MACE, and tirzepatide (against dulaglutide) demonstrated a similar risk reduction in patients at elevated cardiovascular risk with obesity and type 2 diabetes

The goal is not quick weight loss

The mechanisms include blood pressure reduction, improvement in lipid profiles, anti-inflammatory effects on the arterial wall, and possible direct cardioprotective effects through GLP-1R expressed on cardiomyocytes

During this year Black became involved in Garry's research to understand how the intestine selectively absorbed sugars

The STEP 1 trial, which tested semaglutide 2.4mg in adults with obesity, found that approximately 39% of weight lost was lean mass after 68 weeks