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5.2 Potential Risks and Contraindications While Semaglutide has demonstrated efficacy in improving glycemic control, promoting weight loss, and reducing cardiovascular risk factors in individuals with type 2 diabetes and obesity, certain populations may be at increased risk of adverse events or may have contraindications to Semaglutide therapy

Additionally, it suppresses the release of glucagon, a hormone that raises blood glucose levels, and slows gastric emptyingthe rate at which food leaves the stomach and enters the small intestine

Although FDA enforcement against compounding pharmacies has tightened significantly for both medications, semaglutide has had broader compounded availability and lower cost alternatives for longer

Clinical trials have shown different levels of efficacy: semaglutide typically achieves 10-15% weight loss over 68 weeks, while liraglutide generally produces 5-8% weight loss over 56 weeks