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The body composition effects of sustained, physiologically-dosed GH secretion reduced visceral fat, increased lean mass generally improve insulin sensitivity over time

Additionally, individuals may experience a heightened sensitivity in the abdominal area, known as rebound tenderness, which can indicate irritation of the peritoneum surrounding the appendix

A comprehensive literature search across multiple databases identified a total of 6,541 studies, retrieved from PubMed ( n = 848), Web of Science ( n = 1,015), Scopus ( n = 2,523), Embase ( n = 1,525), Cochrane ( n = 367), as well as Google Scholar and manual reference searches ( n = 263)