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2008;34:S73S77

Autophagy in sarcopenia: Possible mechanisms and novel therapies
As a peptide-based injectable targeting GLP-1, GIP, and glucagon receptors simultaneously, retatrutide shares the same temperature sensitivity as approved agents such as semaglutide and tirzepatide

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Doses may be reduced, or cycling strategies may be employed to prevent receptor desensitization and manage long-term costs
