glp-1 for hypothyroidism GLP-1RA and thyroid cancer: New study suggests detection bias, not causation GLP-1 medications can be powerful

The Phase 3 ATTAIN-1 trial had good results that led to this approval, but not all positive: 12.4% average weight loss (27.3 lbs) at highest dose Lower than the 15-20% weight loss seen with injectables Wegovy and Zepbound Nearly 1/4 of participants on the highest dose reported vomiting Vomiting rates are much higher than injectable GLP-1s However, there is likely a niche for Foundayo (along with the pill version of Wegovy) due to convenience: No refrigeration requirements or injection site reactions Eliminates barriers for patients avoiding injectables due to stigma, needle aversion, or storage constraints It's possible we could see this as a "maintenance" therapy after an initial injectable course

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Preclinical studies suggest that GIPR antagonism helps with weight loss and metabolic improvements

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This was a retrospective cohort study of adult patients with a body mass index (BMI)30kg/m2 prescribed GLP-1 analogue therapy at an obesity specialist clinic in Vancouver, Canada