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[(accessed on 22 July 2024)]

Most patients begin at 0.25 mg weekly, then increase by 0.25 mg increments every four weeks until reaching the target dose of 2.4 mg

In the clinical trial, researchers found that many participants crossed below the obesity threshold entirely

Results are more modest, around 8% average weight loss

A study by Gwin and colleagues found that five days of a 30% caloric deficit required a three-fold increase in EAA intake to maintain a positive whole-body protein balance. When those elevated EAA requirements are not met through diet, the body breaks down muscle protein to supply the necessary amino acidsan outcome that cannot be fully reversed until EAA intake catches up

Some plans require strict calorie counting or avoiding whole food groups, which may not work for everyone