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[DOI] [PubMed] [Google Scholar] Schlein R, Westendorf C, Krause G, Rosenthal W

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Written informed consent was obtained from all participants before enrollment

Conclusion GLP-1RA therapy induces sustained receptor signaling while simultaneously reducing nutrient inflow, generating a systemic metabolic state characterized by chronic energy flux constriction

This setback reflects broader challenges associated with therapies targeting the amyloid-beta pathway, which has dominated Alzheimers research for decades

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