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This is largely attributed to glucagon suppression and slow gastric emptying

1 Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus N, Denmark, 2 Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 3 Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark, 4 Department of Clinical Medicine, Aalborg University, Aalborg, Denmark, 5 Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus N, Denmark, 6 Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre+ (MUMC+), Maastricht, Netherlands, 7 Department of Internal Medicine, Maastricht University Medical Centre+ (MUMC+), Maastricht, Netherlands, 8 Department of Internal Medicine, VieCuri Medical Center, Venlo, Netherlands, 9 Department of Clinical Pharmacy, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands

Monitoring: Cardiovascular: Heart rate (at regular intervals during Wegovy therapy) Gastrointestinal: For signs/symptoms of acute pancreatitis (after starting this drug) Metabolic: Blood glucose in patients with diabetes mellitus (before starting and during Wegovy therapy) Ocular: For progression of diabetic retinopathy in patients with history of diabetic retinopathy Renal: Renal function in patients with adverse reactions that could lead to volume depletion (during therapy, especially during initiation and escalation) Patient advice: Read the US FDA-approved patient labeling (Medication Guide and Instructions for Use, as applicable)

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Thats mostly due to how the healthcare system and insurance work there

Semaglutide and tirzepatide were originally developed for diabetes