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More than 17,000 adults Overweight or obesity (body mass index 27 or higher) Established cardiovascular disease (such as prior heart attack, stroke, or peripheral artery disease) No diabetes This was mostly a secondary prevention populationpeople who already had cardiovascular disease

This heightened risk might be associated with the exacerbation of chronic inflammatory states in patients undergoing prolonged combination therapy, potentially facilitating carcinogenic processes [8]

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In fact, some studies found that semaglutide (GLP-1 RA) medications helped people lose an average of 9%-17% of their body weight in a little over a year