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Additionally, much of the research has focused on individuals with metabolic comorbidities, which leaves unanswered questions about the effectiveness of GLP-1 RAs in different populations
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In line with this hypothesis, an observational study of 200 adults with type 1 diabetes demonstrated improvements in albuminuria and in eGFR with SGLT2i use over 12 months among adults with a baseline eGFR 7000 participants identified a 2.8-fold greater risk of DKA with SGLT2i use compared with placebo in adults with type 1 diabetes [44]
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