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Germ cells adjacent to the DTC are in a region called the progenitor zone, which distally contains stem cells, then cells completing a terminal mitotic cell cycle and cells undergoing meiotic S-phase, followed proximally by cells undergoing the earliest stages of meiotic prophase, leptotene and zygotene [4,6,7] ( Fig 1 )

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Levy B, Manove E

But most of the critical quality attributes, potency, purity, sub-visible particles, microbial load, require laboratory testing with specialized equipment like high-performance liquid chromatography (HPLC) and mass spectrometry

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