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In patients with IBD, blood levels and enzymatic activity of DPP4, a key enzyme, were found to be significantly lower compared to healthy individuals or those with inactive diseases, and the degree of reduction correlated with disease activity

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286 It has also been suggested that GLP-1 has synergistic effects on adipocytes with insulin, as basal and acute insulin-stimulated glucose uptake was enhanced by GLP-1 and exendin-4 in differentiated 3T3-L1 adipocytes

Its targeted action on the GH axis makes it unsuitable as a general weight-loss agent, and its use outside of its approved indication would be off-label and unsupported by robust evidence

That said, Ozempic and Mounjaro wont cure diabetes

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