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This is mechanistically distinct from the appetite effect and explains why tirzepatide produces greater fat-mass loss relative to lean-mass loss compared to GLP-1 monotherapy in DEXA substudy data from SURPASS-3 [24]
While there is mixed evidence regarding whether GLP-1RA increase risk for acute pancreatitis and they are associated with thyroid tumors in animals, prescribers should consider these possible adverse effects in patients at elevated risk for either outcome
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November 15, 2012
Other patients in Illinois and North Carolina were hospitalized following injections.
Other Options May Be More Appropriate For People Who: Have been diagnosed with diabetes, prediabetes, or are on blood sugar medications
