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However, we did not find a dose-dependent change in average drinks or AUDIT scores in the medication groups, although a visual downward trend could be observed in the Tirzepatide group

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It is likely that CCK-1R signaling activates vagal afferents at least partly via PKA, as (1) CCK-1R activation increases cyclic adenosine monophosphate 197 , (2) PKA is necessary for CCK to activate central afferent terminals 172 , and (3) duodenal PKA activation leads to vagal afferent firing 196

The rest appears to come from direct effects on immune cells

Li et al., 2003)

Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger