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doi: 10.1128/CMR.3.3.280

However, since furosemide has a broad therapeutic index and is generally dose-adjusted individually, and since rosuvastatin is generally well-tolerated with similar increases in exposures previously being reported as not clinically relevant, the results observed in the present trial are expected to be of no clinical relevance

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In these contexts, it significantly affects nanoparticle delivery, targeting precision, controlled drug release, and overall therapeutic efficacy [504506]