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Studies show that people who stop after 34 months of treatment regain 50% or more of their lost weight within 1 year, even with ongoing diet effort

Metformin also helps lower glucose production and improves insulin sensitivity, both of which aid in weight loss

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The Journal of Rheumatology

Targeting a specific area for fat loss is the realm of surgery, not medication

[4] [5] Patients experiencing symptoms potentially related to cortisol abnormalitiessuch as unexplained weight gain (particularly central obesity), persistent fatigue, muscle weakness, easy bruising, or mood changesshould undergo appropriate evaluation before attributing these to metabolic syndrome alone