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The World Health Organisation's 2026 global guidelines on GLP-1 therapies for obesity explicitly recommend combining medication with intensive behavioural interventions, including structured goal-setting for diet and physical activity

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Structured resistance training (24/week) Adequate protein intake (1.21.6 g/kg/day) Micronutrient optimization (Vitamin D, B12, Omega-3) Avoiding extreme caloric restriction Theres also growing scientific interest in myostatin inhibitors such as Bimagrumab which have shown the ability to preserve lean mass and enhance fat loss when combined with GLP-1 therapies

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