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The global prevalence of 537 million affected in the age group of 2079 years in 2021 will rise to 783 million in 2045, with the lowest increase in incidence in Europe (13%) and the highest in the African countries south of the Sahara (134%) ( Obesity, defined as a body mass index above 30 kg/m 2 , is also increasingly prevalent worldwide and has become a challenge to the various healthcare systems and societies

It identified several overlapping mechanisms: i

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Activation of GLP-1 receptor delays the rate at which the stomach empties, leading to increased satiety and feeling of fullness

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However, the lifestyle intervention guidelines, dating back to 20072008, do not address the need to precisely measure dose, frequency, and type of physical activity or diet and do not suggest ways (e.g., cardiopulmonary exercise testing) other than self-report to monitor intervention compliance or fidelity