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54 For example, AICAR treatment improves glucose tolerance and whole-body glucose disposal, and reduces hepatic glucose output, as well as plasma triglyceride and FFA levels

Patients on maintenance typically move to less frequent check-ins with periodic labs

Bellomo likewise noted that long-term real-world outcomesincluding adherence, discontinuation rates, and sustained lifestyle changeswill ultimately determine whether the drugs produce meaningful improvements in population-level mortality

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Current prescribing information emphasizes individual tolerability and symptom monitoring rather than a fixed week-by-week pattern

This is where GLP-1s step in, offering a glimmer of hope: 54 active clinical trials are currently exploring the use of GLP-1 Drugs in various conditions beyond diabetes and obesity