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There are several serious side-effects that can manifest from their use, some of which can become life-threatening

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Regulating Satiety Pathways: In the hypothalamus, GLP-1 RAs stimulate neurons that promote satiety (POMC/CART neurons) and inhibit neurons that drive hunger (NPY/AgRP neurons), reducing food intake and enhancing fullness (Zheng et al., 2024)

PMID: 41576595, PMCID: PMC12860981, DOI: 10.1016/j.jacadv.2025.102575.Peer-Reviewed Original ResearchConcepts Academic Achievements & Community Involvement Copy Link Activities activity The Obesity Society 2017 - PresentPeer Review Groups and Grant Study SectionsReviewerDetailsGrant Reviewer (Scientific Review Committee) activity The Endocrine Society 2019 - PresentProfessional OrganizationsCommittee MemberDetailsHormone Health Network (HHN) committee activity ADA (American Diabetes Association) 07/01/2019 - PresentMeeting Planning and ParticipationMemberDetailsObesity/Pathogenesis of Obesity Subcommittee activity Obesity - National Childhood Obesity Awareness Month Special Issue 06/01/2021 - PresentJournal ServiceAssociate Editor activity Diabetes Care 2022 - PresentJournal ServiceAssociate Editor Honors honor New York Times Best-Selling Author 02/01/2026National Award honor Clinician of the Year Award, The Obesity Society 01/02/2023National AwardThe Obesity SocietyDetails honor American Board of Obesity Medicine (ABOM), Board of Directors (2022-2025) 05/01/2022National AwardABOMDetails honor Nominated for the Leonard Tow Humanism in Medicine Award Yale Teaching 01/01/2020Yale University AwardYale University honor NIH/NIDDK K23 Mentored Patient-Oriented Research Career Development Award 05/01/2014National AwardDetails Clinical Care Copy Link Overview Ania M

21 Additional favorable effects of HT use include an improvement in glucose metabolism, a reduction in the risk of diabetes, an improvement in the lipid profile, a decrease in the incidence of MASLD, and an overall favorable impact on CVD risk