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Given the heterogeneity of the included evidencespanning case reports, pharmacovigilance analyses, and observational cohortsthis review is framed primarily as a signal-detection and evidence-mapping exercise rather than a causal-inference analysis

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GLP-1-treated cells showed increased glutathione cellular concentrations and the activity of its related enzymes, including glutathione reductase and peroxidase

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GLP-1 medications may increase kidney stone risk through dehydration and uric acid changes, but individual risk depends on baseline kidney function, hydration status, and metabolic factors

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