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EMA (2019) First oral add-on treatment to insulin for treatment of certain patients with type 1 diabetes

doi: 10.1136/bmj.38977.682025.2C

These drugs are essential to prevention of rejection but come at a metabolic cost, disrupting glucose metabolism through several mechanisms, including downregulation of transcription of the adiponectin gene which can lead to greater risk for glucose intolerance

Scarce data exist on the outcomes of AP in patients with T2DM who are taking glucagon-like peptide-1 receptor agonists (GLP-1 RAs)

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Weight loss of at least 5%10% is known to reduce complications of T2D and improve quality of life (Valdecantos et al., 2016)