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Effects of once-weekly subcutaneous semaglutide on kidney function and safety in patients with type 2 diabetes: a post-hoc analysis of the SUSTAIN 1-7 randomised controlled trials

Exendin-4 is a peptide used for the treatment of type 2 diabetes

Experimental and clinical studies suggest that GLP-1 signalling may influence cytokine production, immune cell activation, and tissue inflammation ( In contrast, DPP-4isanother widely used incretin-based therapyhave been consistently associated with dermatologic adverse effects, particularly autoimmune blistering diseases such as bullous pemphigoid ( Although rare cutaneous adverse reactions to GLP-1 RAsincluding hypersensitivity reactions, eosinophilic panniculitis, bullous pemphigoid, and morbilliform drug eruptionshave been reported ( Unlike prior studies that focused on single dermatologic outcomes or non-comparative designs, the present study emulates a target trial to provide comprehensive, comparative dermatologic safety data for GLP-1 receptor agonists versus DPP-4 inhibitors across a broad spectrum of autoimmune and inflammatory skin diseases

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If it's above 7 you're adjusting well

As with GLP-1s, coverage may also require prior authorization, a specific BMI, and consideration of other treatments first