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They bind to specific receptors (SUR1 receptors) on the beta cell membrane, causing closure of ATP-sensitive potassium channels

Seek immediate medical attention (contact 999 or attend A&E) if back pain is accompanied by: Severe, persistent abdominal pain radiating to the back, especially with nausea and vomiting (possible pancreatitis) Loss of bladder or bowel control (potential cauda equina syndrome) Numbness or weakness in both legs (neurological emergency) Fever, unexplained weight loss, or night sweats (possible infection or malignancy) History of trauma or significant injury preceding the pain Contact NHS 111 or your GP or diabetes specialist nurse within 24-48 hours if: Back pain is new, persistent, or progressively worsening since starting Rybelsus Pain significantly interferes with daily activities or sleep You experience unexplained symptoms alongside back pain, such as persistent nausea, changes in bowel habits, or urinary symptoms Pain does not improve with simple analgesia or rest after several days You have concerns about continuing Rybelsus due to the discomfort You develop right upper abdominal pain radiating to the back or shoulder, possibly with fever or jaundice (potential gallbladder disease) According to NICE guideline NG59 on low back pain assessment, healthcare professionals should conduct a thorough history and examination to identify any red flag features suggesting serious pathology

Once we habituate and feel safe, like we're allowed to eat food and eat as much as we want, much of the compulsive energy related to eating subsides

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Speak to your bariatric team about any precautions specific to your situation

Activating these receptors reduces the drive to eat and lowers the reward value of food, meaning food may still taste good, but the compulsive pull toward eating diminishes