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Injection Site Reactions: For injectable GLP-1 agonists, local reactions such as redness, swelling, or itching at the injection site may occur

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Obese humans and animals exhibit leptin resistance in skeletal muscle, decreased muscle mass, reduced fatty acid oxidation and diminished glucose uptake [226], [227], [228]

[1] [3] Given that obesity is itself a major cardiovascular risk factor, significant weight loss is generally associated with improvements in blood pressure, lipid profiles, and markers of systemic inflammation, all of which may benefit heart health