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Elevated resting heart rate is an independent risk factor for adverse outcomes in heart failure, and beta-blocker therapy to reduce heart rate is a cornerstone of HFrEF management

More recently, glucagon receptor activation has emerged as a seemingly paradoxical but potentially powerful addition to incretin-based pharmacotherapy

Jackson C et al, Applying COM-B to medication adherence: A suggested framework for research and interventions
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Treatment discontinuation rates in the ACHIEVE-1 study due to adverse events were 6% (orforglipron 3 mg), 4% (orforglipron 12 mg), and 8% (orforglipron 36 mg) vs
