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A recent review analyzed the role of DPP-4is in patients with T2D and HF, highlighting some controversial results, since some data indicate an increased risk of HF hospitalizations with specific DPP-4is (e.g., saxagliptin), while others report neutral effects, which could indicate effects more related to specific individual molecular characteristics than to a generic common effect of the entire class of drugs [150]

In addition, Sharma et al

43 However, more patients in the liraglutide than placebo group experienced serious cardiac adverse events, including significant arrhythmia

doi: 10.2337/db13-1169 213 NatarajanKXieYBaerMRRossDD

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unlike insulin, which can often lead to weight gain, Ozempic is associated with weight loss in many patients